Creatine REsearch And Information System (CREAS)
CREAS offers curated resources and actionable recommendations to support researchers and academic institutions in advancing creatine-related research.
Creatine is a powerful example of how a natural ocurring compound can impact diverse areas of science and society. The Creatine REsearch And information System (CREAS) is a DBSS project that employs bibliometrics, scientometrics, and AI-assisted methodologies to continuously inform, enhance, and support research initiatives and transformative changes in clinical paradigms.
Bioinformatics
- Annotation
- Cross-referencing
- Gene expression analysis
- Enrichment analysis
- Predicted miRNA-mRNA interactions
Bibliometrics
- Coupling of authors
- Co-authorship of countries
- Co-occurrence of authors’ keywords
- Bibliographic enrichment
Scientometrics
- Web Trends
- Big data text analysis
- Word association thematic analysis
- Opportunities (special issues, conferences)
Clinical Resources
- Creatine For Health
- The CREAS App
- SDGs
- Research Standards
- Ongoing research
Human and Animal Nutrition
Creatine is a vital nutrient renowned not only for its ability to enhance physical performance but also for its growing recognition in supporting overall health across the lifespan and its potential in managing clinical diseases. In animal nutrition, creatine monohydrate is utilized to promote growth and improve muscle quality in livestock, poultry, swine, and aquaculture.
Recent articles
Stay informed with the latest breakthroughs and insights in creatine research. This section features curated studies, reviews, and expert analyses that highlight the ever-expanding applications of creatine. From its impact on brain health and muscle function to its role in metabolic processes and industrial innovation, discover how creatine is shaping the future of science and wellness.
Aging
The power of creatine plus resistance training for healthy aging: enhancing physical vitality and cognitive function.
Bonilla, D. A., Stout, J. R., Candow, D. G., Jiménez-García, J. D., Gómez-Miranda, L. M., Ortiz-Ortiz, M., Forbes, S. C., Ostojic, S. M., Vargas-Molina, S., & Kreider, R. B. (2024). The power of creatine plus resistance training for healthy aging: enhancing physical vitality and cognitive function. Frontiers in physiology, 15, 1496544. https://doi.org/10.3389/fphys.2024.1496544
Current Evidence and Possible Future Applications of Creatine Supplementation for Older Adults
Candow, D. G., Forbes, S. C., Kirk, B., & Duque, G. (2021). Current Evidence and Possible Future Applications of Creatine Supplementation for Older Adults. Nutrients, 13(3), 745. https://doi.org/10.3390/nu13030745
Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation
Candow, D. G., Forbes, S. C., Chilibeck, P. D., Cornish, S. M., Antonio, J., & Kreider, R. B. (2019). Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation. Journal of clinical medicine, 8(4), 488. https://doi.org/10.3390/jcm8040488
Women’s Health
Creatine supplementation during pregnancy: summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy
Dickinson, H., Ellery, S., Ireland, Z., LaRosa, D., Snow, R., & Walker, D. W. (2014). Creatine supplementation during pregnancy: summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy. BMC pregnancy and childbirth, 14, 150. https://doi.org/10.1186/1471-2393-14-150
Creatine Supplementation in Women's Health: A Lifespan Perspective
Smith-Ryan, A. E., Cabre, H. E., Eckerson, J. M., & Candow, D. G. (2021). Creatine Supplementation in Women’s Health: A Lifespan Perspective. Nutrients, 13(3), 877. https://doi.org/10.3390/nu13030877
Creatine and pregnancy outcomes: a prospective cohort study of creatine metabolism in low-risk pregnant females.
Guingand, D. L., Palmer, K. R., Callahan, D. L., Snow, R. J., Davies-Tuck, M. L., & Ellery, S. J. (2024). Creatine and pregnancy outcomes: a prospective cohort study of creatine metabolism in low-risk pregnant females. The American journal of clinical nutrition, 119(3), 838–849. https://doi.org/10.1016/j.ajcnut.2023.11.006
Disease
Creatine: a miserable life without it
Wallimann, T., Harris, R. Creatine: a miserable life without it. Amino Acids 48, 1739–1750 (2016). https://doi.org/10.1007/s00726-016-2297-x
Creatine in Health and Disease
Kreider, R. B., & Stout, J. R. (2021). Creatine in Health and Disease. Nutrients, 13(2), 447. https://doi.org/10.3390/nu13020447
The Application of Creatine Supplementation in Medical Rehabilitation
Harmon, K. K., Stout, J. R., Fukuda, D. H., Pabian, P. S., Rawson, E. S., & Stock, M. S. (2021). The Application of Creatine Supplementation in Medical Rehabilitation. Nutrients, 13(6), 1825. https://doi.org/10.3390/nu13061825
Metabolism
Metabolic Basis of Creatine in Health and Disease: A Bioinformatics-Assisted Review
Bonilla, D. A., Kreider, R. B., Stout, J. R., Forero, D. A., Kerksick, C. M., Roberts, M. D., & Rawson, E. S. (2021). Metabolic Basis of Creatine in Health and Disease: A Bioinformatics-Assisted Review. Nutrients, 13(4), 1238. https://doi.org/10.3390/nu13041238
The creatine kinase system and pleiotropic effects of creatine
Wallimann, T., Tokarska-Schlattner, M. & Schlattner, U. The creatine kinase system and pleiotropic effects of creatine. Amino Acids 40, 1271–1296 (2011). https://doi.org/10.1007/s00726-011-0877-3
Creatine and creatinine metabolism
Wyss, M., & Kaddurah-Daouk, R. (2000). Creatine and creatinine metabolism. Physiological reviews, 80(3), 1107–1213. https://doi.org/10.1152/physrev.2000.80.3.1107
Cognitive Function
Beyond muscle: the effects of creatine supplementation on brain creatine, cognitive processing, and traumatic brain injury
Dolan, E., Gualano, B., & Rawson, E. S. (2019). Beyond muscle: the effects of creatine supplementation on brain creatine, cognitive processing, and traumatic brain injury. European journal of sport science, 19(1), 1–14. https://doi.org/10.1080/17461391.2018.1500644
Effects of creatine supplementation on memory in healthy individuals: a systematic review and meta-analysis of randomized controlled trials
Prokopidis, K., Giannos, P., Triantafyllidis, K. K., Kechagias, K. S., Forbes, S. C., & Candow, D. G. (2023). Effects of creatine supplementation on memory in healthy individuals: a systematic review and meta-analysis of randomized controlled trials. Nutrition reviews, 81(4), 416–427. https://doi.org/10.1093/nutrit/nuac064
The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis
Xu, C., Bi, S., Zhang, W., & Luo, L. (2024). The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis. Frontiers in nutrition, 11, 1424972. https://doi.org/10.3389/fnut.2024.1424972
Exercise & Sport
International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine
Kreider, R. B., Kalman, D. S., Antonio, J., Ziegenfuss, T. N., Wildman, R., Collins, R., Candow, D. G., Kleiner, S. M., Almada, A. L., & Lopez, H. L. (2017). International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition, 14, 18. https://doi.org/10.1186/s12970-017-0173-z
Creatine for Exercise and Sports Performance, with Recovery Considerations for Healthy Populations
Wax, B., Kerksick, C. M., Jagim, A. R., Mayo, J. J., Lyons, B. C., & Kreider, R. B. (2021). Creatine for Exercise and Sports Performance, with Recovery Considerations for Healthy Populations. Nutrients, 13(6), 1915. https://doi.org/10.3390/nu13061915
The birth of modern sports nutrition: tracing the path from muscle biopsies to creatine supplementation-A narrative review
Stout, J. R., Kreider, R. B., Candow, D. G., Forbes, S. C., Rawson, E. S., Antonio, B., & Antonio, J. (2025). The birth of modern sports nutrition: tracing the path from muscle biopsies to creatine supplementation-A narrative review. Journal of the International Society of Sports Nutrition, 22(sup1), 2463373. https://doi.org/10.1080/15502783.2025.2463373
Safety
Safety of creatine supplementation: analysis of the prevalence of reported side effects in clinical trials and adverse event reports
Kreider RB, Gonzalez DE, Hines K, Gil A & Bonilla DA. Safety of creatine supplementation: analysis of the prevalence of reported side effects in clinical trials and adverse event reports. Journal of the International Society of Sports Nutrition, Volume 22, 2025 – Issue sup1. doi. https://doi.org/10.1080/15502783.2025.2488937
Creatine supplementation is safe, beneficial throughout the lifespan, and should not be restricted
Kreider RB, Jagim AR, Antonio J, Kalman DS, Kerksick CM, Stout JR, Wildman R, Collins R and Bonilla DA (2025) Creatine supplementation is safe, beneficial throughout the lifespan, and should not be restricted. Front. Nutr. 12:1578564. doi: https://doi.org/10.3389/fnut.2025.1578564
Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show?
Antonio, J., Brown, A. F., Candow, D. G., Chilibeck, P. D., Ellery, S. J., Forbes, S. C., Gualano, B., Jagim, A. R., Kerksick, C., Kreider, R. B., Ostojic, S. M., Rawson, E. S., Roberts, M. D., Roschel, H., Smith-Ryan, A. E., Stout, J. R., Tarnopolsky, M. A., VanDusseldorp, T. A., Willoughby, D. S., & Ziegenfuss, T. N. (2025). Part II. Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show?. Journal of the International Society of Sports Nutrition, 22(1), 2441760. https://doi.org/10.1080/15502783.2024.2441760
Animal Nutrition
Changes of tissue creatine concentrations upon oral supplementation of creatine-monohydrate in various animal species
Ipsiroglu, O. S., Stromberger, C., Ilas, J., Höger, H., Mühl, A., & Stöckler-Ipsiroglu, S. (2001). Changes of tissue creatine concentrations upon oral supplementation of creatine-monohydrate in various animal species. Life sciences, 69(15), 1805–1815. https://doi.org/10.1016/s0024-3205(01)01268-1
Creatine: A valuable supplement in aquafeeds?
Wuertz, S., & Reiser, S. (2023). Creatine: A valuable supplement in aquafeeds?. Reviews in Aquaculture, 15(1), 292-304. https://doi.org/10.1111/raq.12717
Creatine in sustainable fish aquaculture
Villasante, A., Ramírez, C., Figueroa Villalobos, E., Pereira, W. A., Powell, M. S., Gatlin III, D. M., … & Romero, J. (2023). Creatine in sustainable fish aquaculture. Reviews in Fisheries Science & Aquaculture, 31(3), 420-451. https://doi.org/10.1080/23308249.2023.2210689
Public Health
Research highlights the importance of dietary creatine for optimal health, growth, and aging. Creatine monohydrate plays a key role in preventing sarcopenia (age-related muscle loss) and improving the quality of life in older adults, making it a valuable tool for promoting healthy aging.